Melanotan II

Investigated uses

• No adequately documented human investigated use for the exact catalog identity/formulation was identified; any vendor-promoted goals were excluded from evidence grading.

Mechanism and hypotheses

• Melanotan II is a cyclic, nonselective melanocortin-receptor agonist studied in limited human pharmacology.
• Hypothesized: Tanning and sexual-function effects do not establish a safe unapproved product or route.

Human evidence

• Limited human pharmacology demonstrated melanocortin effects, but no approved indication or formulation was identified. Limitations: Small studies and extensive gray-market confounding; long-term safety is unknown.

Safety highlights

• Nausea, flushing, yawning, spontaneous erections and pigmentary changes have been reported.
• Case reports and regulator concerns include priapism, blood-pressure effects and changing nevi; causal incidence is unknown.

Regulatory context

No FDA-approved Melanotan II drug was identified; FDA lists Melanotan II among substances presenting significant compounding safety concerns.