Humanin

Investigated uses

• No adequately documented human investigated use for the exact catalog identity/formulation was identified; any vendor-promoted goals were excluded from evidence grading.

Mechanism and hypotheses

• Humanin is a mitochondrial-derived peptide with cytoprotective effects in laboratory and animal models.
• Hypothesized: Anti-aging, metabolic and neuroprotective human effects remain unestablished.

Human evidence

• Cytoprotective and metabolic effects are reported in laboratory and animal models. Limitations: No safe or effective human dose has been established.

Safety highlights

• Unknown or insufficiently characterized for the exact catalog product.
• Identity, purity, sterility, endotoxin, aggregation, immunogenicity, concentration and route-specific risks are not adequately characterized.

Regulatory context

No FDA-approved product matching the exact catalog presentation was identified in this review.